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EC number: 807-840-4
CAS number: 64896-70-4
DOI was tested in a HRIPT test, with 53
panelists exposed to nine consecutive 24 hours exposures to the test
material diluted at 20% in corn oil, under occlusive conditions.
Subjects were then given a rest period after which a challenge or retest
dose was applied.
No adverse reactions of any kind were noted
during the course of this study. The test material when tested under
occlusive conditions at 20% dilution in corn oil may be considered as a
non-primary irritant and a non-primary sensitizer to the skin according
this HRIP test.
An OECD and GLP assay was also available on
the similar substance DEI.
Skin sensitising potential of DEI was
evaluated in the female mouse CBA/J using an in-vivo non-radioactive
Local Lymph Node Assay (LLNA) test method in accordance with the General
Requirements of OECD Guideline No. 429. Under the experimental
conditions, DEI did not induce delayed contact hypersensitivity in the
murine Local Lymph Node Assay using CBA/J female mice after three
consecutive days of treatment.
Based on the
classification criteria of Annex VI Directive 67/548/EEC or UN/EU GHS,
and by analogy with the similar substance DEI, no classification of DOI
for skin sensitisation is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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