Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

DOI was tested in a HRIPT test, with 53 panelists exposed to nine consecutive 24 hours exposures to the test material diluted at 20% in corn oil, under occlusive conditions. Subjects were then given a rest period after which a challenge or retest dose was applied.

No adverse reactions of any kind were noted during the course of this study. The test material when tested under occlusive conditions at 20% dilution in corn oil may be considered as a non-primary irritant and a non-primary sensitizer to the skin according this HRIP test.

An OECD and GLP assay was also available on the similar substance DEI.

Skin sensitising potential of DEI was evaluated in the female mouse CBA/J using an in-vivo non-radioactive Local Lymph Node Assay (LLNA) test method in accordance with the General Requirements of OECD Guideline No. 429. Under the experimental conditions, DEI did not induce delayed contact hypersensitivity in the murine Local Lymph Node Assay using CBA/J female mice after three consecutive days of treatment.


Migrated from Short description of key information:
No indication of skin sensitization potential in vivo in mice (LLNA), by analogy with DEI.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the classification criteria of Annex VI Directive 67/548/EEC or UN/EU GHS, and by analogy with the similar substance DEI, no classification of DOI for skin sensitisation is required.