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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Description of key information

The Log Kow of the substance Isosorbide Dioctanoate is predicted to be 4.46 based on QSARs.

Key value for chemical safety assessment

Log Kow (Log Pow):
4.46
at the temperature of:
25 °C

Additional information

According to column 2 Annex VII of Reach and also the Guidance R7a, the log Kow tests (shale flask method and HPLC method) cannot be performed if the substance shows tensio-active properties. Therefore a calculation value was proposed for the log Kow determination.

The Log Kow of the substance Isosorbide Dioctanoate is predicted to be 4.46, which is the mean of the log Kow of 4.89 and 4.02 obtained with the KOWWIN model and VEGA model respectively. These two predictions of the log Kow obtained with different QSARs models are taken into account in a weight of evidence approach.