Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 807-840-4 | CAS number: 64896-70-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No lethal effect was observed on Danio rerio at the loading rate of 100 mg/L after 96 hours.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
The acute toxicity on fish of the isosorbide diesters (EC No. 700 -073 -5) has been determined according to the OECD Guideline 203 (semi-static conditions) and in compliance with the GLP.
Due to the very low solubility of the tested substance and its UVCB nature, and in conformity with the Document OCDE N° 23 (Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures) WAFs were prepared at 1, 10 and 100 mg/L. No mortality was observed on the fish exposed to these different loading rates, therefore the LLO ≥ 100 mg/L (highest tested loading rate)
The substance Isosorbide di-octanoate (CAS No. 64896-70-4 ) was considered to show a LLO ≥ 100 mg/L on the basis of the results obtained in this acute fish test performed with a very similar analogue.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
