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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

No immobilisation was observed on Daphnia magna after 48h of exposure to the maximum soluble tested concentration of 1.2 mg/L. 

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1.2 mg/L

Additional information

The toxicity of the substance Isosorbide dioctanoate (CAS 64896-70-4 ) on Daphnia magna has been evaluated according to the OECD Guideline 202 and in compliance with GLP.

This acute test was done under static conditions. A maximum solubility of 1.2 mg/L was obtained for the substance in the test medium using acetone (0.01 ml/L) and this concentration was applied in a limit test.

More than 80% of the nominal concentration was measured at T0. Moreover the stability of the substance in the test medium was controled during the method validation and the substance was demonstrated stable during 48 hours. The results are expressed as nominal concentration.

No immobilisation of the daphnids was observed at the maximum tested concentration of 1.2 mg/L and all the validity criteria were met.

The substance Isosorbide dioctanoate shows a EC50 > 1.2 mg/L and a EC0 1.2 mg/L on Daphnia magna in the conditions of the test.