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EC number: 482-020-3
CAS number: -
No remarkable body weight changes were noted during the study.
There were no deaths during the study.
The primary ocular irritation potential of Consolidated Cyclohexane
Dicarboxaldehydes was evaluated in this study with New Zealand White
rabbits. There was one group of three albino rabbits that received a
single, unwashed exposure. Each 0.1- ml dose of the test article was
instilled into the lower conjunctival sac of the right eye. The eyelid
was held closed for approximately one second and released. The left eye
was manipulated in a similar manner as the right eye and served as a
contralateral control. The eyes were examined for ocular reactions in
accordance with the method of Draize at approximately one, 24, 48 and 72
hours after dosing and on study days 4, 7, 10, 17 and 21, if irritation
persisted. Sodium fluorescein was used to aid in revealing possible
corneal damage at
24 hours and at all subsequent observations. All animals were noted with
positive corneal (grade 1-2 for opacity, grade 4 for area), iridal
(grade 1) and conjunctival (grade 2-3 for redness, grade 3-4 for
chemosis) findings. Irritation for two animals completely subsided by
study days 10 or 17. Corneal and conjunctival findings were still
present at study termination for one animal. Additionally, this animal
was observed with corneal neovascularization on study days 10 and 17.
The Maximum Average Score for Consolidated Cyclohexane Dicarboxaldehydes
was 41.0 at 24 hours post-instillation.
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