Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 482-020-3
CAS number: -
The in vivo genotoxic potential of 1,3 and 1,4-cyclohexanecarboxaldehyde
was evaluated by
examining the incidence of micronucleated reticulocytes (MN-RET) in the
The test material was administered to male Crl:CD1(ICR) mice by single
oral gavage on two
consecutive days at dose levels of 0 (negative control), 500, 1000, and
2000 (limit dose)
mg/kg body weight (bw). The highest dose level of 2000 mg/kg bw/day was
based upon the
results of a range-finding test where at this dose, no treatment-related
deaths were observed
in male or female mice. The analytically determined concentrations of
the test material in the
dosing solutions used for the first day of dosing in the micronucleus
ranged from 86.3% to
93.8% of the targeted concentrations. All animals were observed for
clinical signs prior to
dosing and at 2, 5, and 24 hours following each dosing. Groups of
animals were euthanized
48 hours after the second treatment for the collection of peripheral
blood and evaluation of
RET (approximately 5,000/animal) for MN by flow cytometry. The
proportion of RET was
also determined based upon 5,000 RET per animal and the results
expressed as a percentage.
Mice treated with 40 mg/kg bw cyclophosphamide monohydrate by a single
gavage dose and
euthanized 48 hours later served as positive controls.
All animals survived to the end of the observation period.
Treatment-related clinical signs
including decreased feces and perineal soiling were noted in the 2000
treatment group. There were no statistically significant increases in
the frequencies of MNRET
or statistically significant effects on the percent RET in groups
treated with the test
material as compared to the negative controls. There was a significant
increase in the
frequency of MN-RET and a decrease in the percentage of RET in the
chemical group as compared to the negative control group. Based upon the
results of the study reported herein, it was concluded that the test
material, 1,3 and 1,4-
cyclohexanecarboxaldehyde, did not induce a significant increase in the
micronucleated reticulocytes in the peripheral blood when given by daily
gavage on two
consecutive days to male Crl:CD1(ICR) mice. Therefore, 1,3 and 1,4-
cyclohexanecarboxaldehyde is considered negative in this test system
under the experimental
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again