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EC number: 482-020-3
CAS number: -
This study was conducted to determine the acute inhalation toxicological
properties of 1,3- and 1,4-cyclohexanecarboxaldehyde. Groups of five
rats/sex were exposed for four hours, using a nose-only inhalation
exposure system, to a time-weighted average chamber
concentration of 5.22 mg 1,3- and 1,4-cyclohexanecarboxaldehyde per
liter of air. The mass median aerodynamic diameter (MMAD) of particulate
1,3- and 1,4- cyclohexanecarboxaldehyde present in the exposure chamber
test atmosphere averaged 3.71 microns with an average geometric standard
deviation of 2.11 microns. All animals survived the four-hour exposure
to the test material as well as the two-week post-exposure period.
Clinical effects noted during the four-hour exposure period were limited
to soiling of the haircoat in one male and three female rats. In-life
observations noted post-exposure included perineal, perinasal and/or
extensive body soiling in four males and three females, noisy
respiration in one male and a partially closed eye in one female. All
rats appeared normal by test day 6. Mean body weight losses of 11.4 and 6.7%
were noted for male and female rats, respectively, on test day 2.
Pre-exposure mean body weight values were exceeded on test day 8. There
were no visible treatment related lesions noted in any of the rats
exposed to 1,3- and 1,4 -cyclohexanecarboxaldehyde at the test day
15-scheduled necropsy. Based on these data, the four-hour LC50 of
inhaled particulate 1,3- and 1,4- cyclohexanecarboxaldehyde is greater
than 5.22 mg/L for male and female F344/DuCrl rats.
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