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EC number: 482-020-3
CAS number: -
Table 1: Summary of Clinical Findings - Males
1- 5000 MG/KG
Table 2: BODY WEIGHTS (GRAMS)
Table 3: GROSS NECROPSY OBSERVATIONS INCIDENCE SUMMARY
The acute percutaneous toxicity of Consolidated Cyclohexane
Dicarboxaldehydes was evaluated in this single-dose study in rabbits.
The test article was administered once cutaneously at a dose level of
5000 mg/kg to a group of five male and five female albino rabbits for a
24-hour period under occlusive dressing.
Mortality, clinical observations, cutaneous findings (Method of Draize,
Appendix A) and body weight changes were evaluated over a 14-day
observation period. All animals were subjected to a gross necropsy.
There were no deaths during the study. Nine animals were noted with
transient soft feces on study days 0, 1 and/or 3. One animal was
noted with dried brown material around the urogenital area on study day
3. All animals appeared normal by study day 4 and throughout the
remainder of the study. There were no other clinical findings.
Severe skin irritation was observed for all animals. Severe erythema and
edema, eschar, corrosion and exfoliation were observed for all animals.
Blanching, subcutaneous hemorrhage and purple discoloration were noted
for nine, seven and four animals, respectively. In addition, desquamation
was observed for all rabbits. There were no other cutaneous findings. Although
minor fluctuations in body weight were noted, all animals met or
exceeded their initial (study day 0) body weight at termination. There
was an effect from study day 0 to 7 which was test article-related and
most likely due to severe skin irritation and not systemic toxicity. No remarkable
body weight changes were noted from study day 7 to 14. All animals were
noted with scabbing of the application site and five animals were noted
with a thickened application site. There were no other treatment-related
gross necropsy findings for any examined tissues.
The LD50 of Consolidated Cyclohexane Dicarboxaldehydes was greater than
5000 mg/kg when administered once for 24 hours to the clipped, unabraded
skin of male and female albino rabbits.
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