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EC number: 482-020-3
CAS number: -
TABLE 1: INCIDENCE OF MORTALITY AND TOTAL MORTALITY DURING THE FINAL TEST
Table 2: CLINICAL EFFECTS OBSERVED DURING THE FINAL TEST
Carp (Cyprinus carpio) were exposed to Unoxol 3,4 Dialdehyde under
semi-static conditions with daily renewals for 96 hours. Measured
concentrations were close to the nominal loading rate. Temperature, pH,
and dissolved oxygen levels were within required specifications for the
test organism. Under the conditions of the present test, Unoxol 3,4
Dialdehyde induced no visible effects in carp at 10 mg/L (NOEC). The
96-hour LC50 was 26 mg/L based on measured concentrations (95%
confidence interval between 24 and 33 mg/L).
The 96-hour LC50 value of 26 mg/L for Unoxol 3,4-Dialdehyde was taken from a valid, acute, exposure study with carp (Cyprinus carpio).
Two acute freshwater fish studies were assessed for this endpoint. One
study was conducted with carp (Cyprinus carpio), and this study
was determined to be acceptable for use in risk assessment (Klimisch
score = 1). The other study was conducted with Chinese rare minnows (Gobiocyprus
rarus), and was determined to be acceptable for use in risk
assessment (Klimisch score = 1). Both fish acute studies exposed the
test organisms to a series of five test concentrations and a negative
(dilution water) control for 96 hours in a static-renewal exposure
system. In both studies, test solutions were renewed
every 24 hours. Observations of mortality and other
signs of toxicity were made at or shortly after test initiation, as well
as 24, 48, 72 and 96 hours after test initiation. The 96-hour LC50 was
determined to be 26 mg/L in the fish acute study with carp. The
96-hour LC50 was determined to be 65.1 mg/L in the fish acute study with
the Chinese rare minnows. Based on these results, the
carp study was selected as the key study since the LC50 value was lower
for this species.
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