Registration Dossier
Registration Dossier
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EC number: 203-545-4 | CAS number: 108-05-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline in vitro study, published in peer reviewed literature, minor restrictions in reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Expression and activities of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth
- Author:
- Dong Y, Peng T, Yin S
- Year:
- 1 996
- Bibliographic source:
- Alcohol, 13, 257-262
Materials and methods
- Study type:
- other: in vitro
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in human gingiva and lingual tissue were determined in vitro.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetaldehyde
- EC Number:
- 200-836-8
- EC Name:
- Acetaldehyde
- Cas Number:
- 75-07-0
- Details on test material:
- - Name of test material (as cited in study report): acetaldehyde
- Source: E. Merck, Darmstadt, Germany
- Purity: analytical grade and redistilled before use
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Subjects exposed: Adult donors
- Number of subjects exposed: 24
- Age: 42 ± 12 years
- Race: Chinese
- Other: with no history of alcoholism. Gingiva and lingual mucosa were used for the in vitro enzyme assay - Ethical approval:
- confirmed, but no further information available
- Details on exposure:
- Tissue samples were homogenised, centrifuged and the supernatants used for enzyme activity measurements. ALDH activity was determined spectrophotometrically using acetaldehyde as substrate. ALDH isozymes were identified using isoelectric focussing. Kinetic data were evaluated using the HYPER statistical program.
Results and discussion
- Results of examinations:
- Class IIIx-ALDH3 was detected in oral mucosa. Human oral ALDH activities (Vmax at a substrate concentration of 20 mM) were 4.25 ± 0.57 and 1.82 ± 0.10 nmol/min/mg protein in gingiva (n=24) and tongue (n=3) respectively.
Applicant's summary and conclusion
- Conclusions:
- ALDH activity was detected in gingiva and lingual tissue; this activity was associated with a high Km isozyme (ALDH3).
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