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EC number: 203-545-4
CAS number: 108-05-4
Groups of 5, unfasted, male rats were dosed
orally (by stomach intubation) with undiluted vinyl acetate at dose
volumes of 2, 4 or 8 mL/kg and were then observed for 14 days. At 8
mL/kg, all five rats died within 1 day of dosing and 3/5 rats dosed at 4
mL/kg died, again on day 0 or 1. At 2 mL/kg all rats survived. The only
clinical signs were sluggish behaviour seen in high dose animals. Gross
post mortem changes included congestion throughout the lungs and
abdominal viscera and mottling of the livers. The acute oral LD50 for
vinyl acetate to male rats was 3.73 (2.52-5.59) mL/kg, equivalent to
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