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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Undiluted vinyl acetate at 3 dose volumes (2, 4 and 8 mL/kg). 5 male rats per group. Observed for 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl acetate
EC Number:
203-545-4
EC Name:
Vinyl acetate
Cas Number:
108-05-4
Molecular formula:
C4H6O2
IUPAC Name:
ethenyl acetate
Details on test material:
- Name of test material (as cited in study report): Vinyl acetate
- Physical state: Liquid
- Supplier: Union Carbide Corporation, Chemicals and Plastics Division, South Charleston, W. Va., USA

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Mellon Institute, Carnegie-Mellon University
- Age at study initiation: 3-4 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: Non fasted
- Housing: Not reported
- Diet: Rockland diet ad libitum
- Water: ad libitum
- Acclimation period: Not reported

ENVIRONMENTAL CONDITIONS: Not reported

IN-LIFE DATES: Not reported

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2, 4 and 8 mL/kg
No. of animals per sex per dose:
5 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Statistics:
LD50 calculated by the moving average method

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3.73 mL/kg bw
95% CL:
2.52 - 5.59
Remarks on result:
other: 3470 mg/kg
Mortality:
0, 3/5 and 5/5 deaths at dose volumes of 2, 4 and 8 mL/kg respectively. All mortalities were on days 0 or 1.
Clinical signs:
other: At 8 mL/kg, animals were reported to be sluggish. No clinical signs were reported at the other dose volumes.
Gross pathology:
Congestion throughout lungs and abdominal viscera, livers mottled.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The acute oral LD50 for vinyl acetate to male rats was 3.73 (2.52-5.59) mL/kg, equivalent to 3470 mg/kg.
Executive summary:

Groups of 5, unfasted, male rats were dosed orally (by stomach intubation) with undiluted vinyl acetate at dose volumes of 2, 4 or 8 mL/kg and were then observed for 14 days. At 8 mL/kg, all five rats died within 1 day of dosing and 3/5 rats dosed at 4 mL/kg died, again on day 0 or 1. At 2 mL/kg all rats survived. The only clinical signs were sluggish behaviour seen in high dose animals. Gross post mortem changes included congestion throughout the lungs and abdominal viscera and mottling of the livers. The acute oral LD50 for vinyl acetate to male rats was 3.73 (2.52-5.59) mL/kg, equivalent to 3470 mg/kg.