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EC number: 203-545-4
CAS number: 108-05-4
In accordance with REACH guidance (Appendix
R.8-13) and since no new scientific information has been obtained under
REACH which would contradict the use of the proposed IOELV, for the
purposes of this submission the proposed IOELVs (STEL and 8-h TWA) are
used in place of acute and long-term DNELinhalation values for workers.
In accordance with REACH guidance (R.8), DNEL values are proposed since
vinyl acetate has a threshold mode of action i.e. NOAEL/NOAECs are
identified for all relevant endpoints. The IOELV has been established
based on the NOAEC of 50 ppm for histological changes in respiratory
tissues of rodents and, based on limited observations in humans, the
reported threshold for irritancy in humans, considered to be 10 ppm.
The adopted STEL is 10 ppm (35.2 mg/m³) and
8 h TWA, 5 ppm (17.6 mg/m³), as concluded by SCOEL in October 2005
(SCOEL/SUM/122) and published in December 2009 (EC, 2009).
15% absorption (uptake) via inhalation, 50%
via oral and 90% dermal absorption (both values are used in concurrence
with the RAR).
Reference: EC (2009) Commission Directive
2009/161/EU of establishing a third list of indicative occupational
exposure limit values in implementation of Council Directive 98/24/EC
and amending Commission Directive 2000/39/EC.
Based on the identified uses for vinyl
acetate, no DNELs are proposed since relevant exposure of the general
population is not expected due to the following reasons:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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