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EC number: 203-545-4
CAS number: 108-05-4
The most conservative value reported is a
34d NOEC of 0.551 mg/L for Pimephales promelas. This is reported in the
study by Marino et al., (2003) which is GLP compliant and near
guideline. There was difficulty in maintaining the test concentrations
and the measured test solution concentrations were variable and did not
remain within ± 20% of the mean measured concentrations over the course
of the study. Despite this, the reported value of 0.551 mg/L has been
used in the derivation of the PNECaqua in the Draft EU RAR (2008).This
result was not based on the Time Weighted Average, recommended in the
OECD test guidelines, and therefore the NOEC has been recalculated,
using the raw data provided in the report to give a NOEC of 0.16 mg/L.
This value was used to derive the PNECaqua.
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