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EC number: 202-486-1
CAS number: 96-18-4
- table 1: exposure concentrations and chamber conditions
Target Conc. (ppm)
Temp. (°C) (c)
Analytical concentration (a)
Coefficient of variation (b)
Mean ± SD
Rel. Hum. (%) (c)
(a) Numbers are X ± SD daily time-weighted average (TWA) values
for 9 exposures.
(b) Coefficient of variation is the SD of the daily TWA
measurements divided by X (X100).
(c) X ± SD of daily measurements for 9 exposure days.
(d) On day 8, the 10 ppm exposures were conducted for. only 4.5
hours instead of 6 hours as a result of an operational error.
The present study DOW HET-K-002524-006 / (F344 rat and B6C3F1 mouse, 14d
repeated dose inhalation toxicity lower doses) was a follow up study to
DOW HET-K-002524-004 / (F344 rat and B6C3F1 mouse, 14d repeated dose
inhalation toxicity, higher doses) and conducted to asses the NOAEC for
1,2,3 -Trichloropropane for rats and mice after repeated inhalation
exposure (4 h/d, 9 exposures in 14 d, concentrations: 0, 6, 18 or 60
mg/m³ (0, 1, 3 or 10 ppm)). NOAECs of 6 mg/m³ (1 ppm) for the rat and 18
mg/m³ (3 ppm ) for the mouse were found, the corresponding LOAECs are 18
mg/m³ (3 ppm) for the rat and 60 mg/m³ (10 ppm) for the mouse.
Male and female Fischer 344 rats and B6C3F1 mice were analyzed daily for
clinical signs, expect on weekends. Body weights were measured prior to
the 1st , 3rd, 5th and 9th exposures. In rats urinalysis was conducted
at the morning prior to the 9th exposure. At the end of the study the
animals were sacrificed and subjected to gross necroscopy and
histological analysis of various tissues.
Body weights, organ weights and urinalyses were unaffected by the TCP
exposures. Histopathologic examinations of the nasal tissues revealed
very slight exposure-related changes in the olfactory epithelium of rats
in the 3 ppm and 10 ppm groups, as well as in mice in the 10 ppm group.
Similar effects on the olfactory epithelium had previously been found in
rats and mice exposed to 13 ppm TCP vapors in a previous study; more
pronounced effects on nasal tissues occurred in animals exposed t o 40
or 132 ppm (DOW HET-K-002524-004 / (F344 rat and B6C3F1 mouse, 14d
repeated dose inhalation toxicity, higher doses)).
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