Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: - very limited report in an review paper on the sensory irritation of different industrial chemicals

Data source

Reference
Reference Type:
publication
Title:
Further Studies on Sensory Response to Certain Industrial Solvent Vapors
Author:
Silverman L, Schulte, HF & First MW
Year:
1946
Bibliographic source:
Journal of Industrial Hygiene and Toxicology. 28 (6): 262-6

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
respiratory irritation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
12 volunteers were exposed to vapors of 1,2,3-trichloropropane of different concentrations for 15 min and acceptance levels were determined
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Trichloropropane
- specified as: CH2ClCHClCH2Cl (= 1,2,3-trichloropropane)
- specified by: boiling point (156.17 °C) and vapor pressure (8.5 mmHg at 40 °C)
- no further details given

Method

Type of population:
not specified
Subjects:
no data
Ethical approval:
not specified
Route of exposure:
inhalation
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
- subjects were exposed at least to 50 and 100 ppm (= 300 and 600 mg/m³), probably also to higher concentrations that were not noted
Examinations:
no detailed description
Medical treatment:
not applicable

Results and discussion

Clinical signs:
- all subjects objected to concentrations of 100 ppm or higher during exposure for 15 min due to irritation of eyes and throat.
- at 50 ppm a borderline majority found this concentration acceptable for a 8 h shift

Applicant's summary and conclusion

Conclusions:
The respiratory sensory irritation threshold limits for 1,2,3-trichloropropane was tested in human volunteers during an exposure of 15 min to 50 and 100 ppm.
A borderline majority of the subjects found a concentration of 50 ppm (= 300 mg/m³) acceptable for an 8 h shift. All subjects objected to 100 ppm (= 600 mg/m³) due to irritation of eyes and throat.
Executive summary:

In the present study (Silverman 1946) the respiratory sensory irritation threshold limits for 1,2,3-trichloropropane was tested in human volunteers during an exposure of 15 min to 50 and 100 ppm.

A borderline majority of the subjects found a concentration of 50 ppm (= 300 mg/m³) acceptable for an 8 h shift. All subjects objected to 100 ppm (= 600 mg/m³) due to irritation of eyes and throat.