Registration Dossier
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EC number: 202-486-1 | CAS number: 96-18-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- The classification of the key parameter is based on results of the study Shell Development Company (1980C) / key (Hartley-Albino guinea pigs, Buehler Test, OECD TG 406) considered to be fully reliable and compliant to OECD TG 406 by the SIDS INITIAL ASSESSMENT REPORT For SIAM 18 - 1,2,3-Trichloropropane as at 2004. Shell Development Company (1980C) / key (Hartley-Albino guinea pigs, Buehler Test, OECD TG 406). In an additional study that is only available from a secondary source this finding is confirmed (guinea pig maximisation test; Bio/dynamics Inc. (1985), Buehler test). In Clark (1977, guinea pig maximisation test) slight positive results were found. Nevertheless these effects would not be sufficient for classification. Anyway the study is regarded unreliable as the study was conducted with 1,2,3 -trichloropropane of a purity of 92 % without any information on the nature of the impurities.
Therefore 1,2,3 -trichloropropane is deemed not to be a skin sensitizer which is in-line with the current classification and labelling.
Migrated from Short description of key information:
not sensitising, (OECD TG 406, guinea pig maximisation test); study Shell Development Company (1980C) / key (Hartley-Albino guinea pigs, Buehler Test, OECD TG 406)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- No information on the sensitising potential of 1,2,3-trichloropropane via the inhalation route is available. As 1,2,3-trichloropropane is not a sensitizer via the dermal route the risk that the substance is a respiratory sensitizer is regarded negligible.
Migrated from Short description of key information:
- No information on the sensitising potential of 1,2,3-trichloropropane via the inhalation route is available.
Justification for classification or non-classification
- Based on the results presented above, 1,2,3 -chloropropane is not a skin sensitizer and therefore does not need to be classified for skin sensitization according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL).
- No information on the sensitising potential of1,2,3 -chloropropane via the inhalation route is available. As 3-chloropropene is not a sensitizer via the dermal route the risk that 3-chloropropene is a respiratory sensitizer is regarded negligible. Based on this reasoning 3 -chloropropene does not need to be classified for respiratory sensitization according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL).
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