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EC number: 202-486-1
CAS number: 96-18-4
In the present study (Shell Developmental Company 1980C)
1,2,3-trichloropropane was tested for its skin sensitizing properties
using the Buehler Test with male and female Dunkin-Hartley guinea pigs
in general compliance to OECD TG 406 as at 1980. The test item was
tested at the highest non irritating concentration as derived from a
pretest (0.5 mL of neat test item) under occlusive conditions for 6 h
per exposure (3 induction exposures, 1 challenge exposure). None of the
animals in the test group showed a sensitization reaction, while the
positive test group (agent: 2,4-dinitro chlorobenzene) showed the
sensitivity of the test system. Based on this result
1,2,3-trichloropropane is not a skin sensitizer in this test system and
a classification for skin sensitization CLP (REGULATION (EC) No
1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as
implementation of UN-GHS in the EU is not necessary.
5 males and 5 females per group were clipped on the back 48 prior to
treatment and finally depilatated with Neet hair remover 24 h prior to
treatment. 4 groups were used: a "vehicle" control group (corn oil, even
though in the treatment groups the test material was applied undiluted),
a positive control group (agent: 2,4-dinitro chlorobenzene) and two test
groups - one for sensitization and one for irritation. The irritation
group and the "vehicle" control group were not treated with the test
item during the induction, while the two other groups were treated with
the respective substance on day 2, 9 and 26. Substances were applied to
patches which were placed laterally from the midline of the back on the
left front quadrant of the exposure areas with the gauze pads adjacent
to, but not overlapping, the midline of the backs. On day 30 the two
test groups were treated similarly with 1,2,3 -trichloropropane but on a
different site, laterally on the right rear quadrant. Positive and
negative controls were treated accordingly and all animals were scored
for skin reactions 24 and 48 h after challenge exposure using the Draize
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