Registration Dossier
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EC number: 202-486-1 | CAS number: 96-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
TCP exhibits acute effects on aquatic micro-organisms.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 290 mg/L
Additional information
Blum & Speece (1991) report results from four different assays employing micro-organism communities and specific strains. However methanogens were most susceptible with regard to the endpoint inhibition of gas production (48-h IC50 0.63 mg/L), the aerobic heterotrophic community with the endpoint inhibition of oxygen uptake represent the relevant community for assessment. The study protocol is comparable to OECD TGD 209 and the study is considered valid and conclusive and yielded a 24-h IC50 of 290 mg/L.
The assay employing nitrifying bacteria (Nitrosomonas sp.) with the endpoint inhibition of ammonia consumption revealed an 24-h IC50 of 30 mg/L. This is in agreement with ECHA (2008, information requirements and chemical safety assessment, chapter R.10., p 30) who recommends an assessment factor (AF) of 10 to be applied to result of a sludge respiration test, reflecting the lower sensitivity of this endpoint as compared to nitrification.
Finally a Microtox® model 2055 assay (ISO 11348) employing a specific bacterial population (Vibrio fischeri) with the endpoint inhibition of bioluminescence showed an 5-min IC50 value of 19 mg/L.
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