Registration Dossier

Administrative data

Description of key information

- skin irritation:             not irritating  for the rabbit skin; Shell Development Company (1980A) / key (rabbit skin irritation) 
- eye irritation: irritating for the rabbit eye; Shell Development Company (1980B) / key (rabbit skin irritation)
- respiratory irritation: no test available

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

- skin irritation: The classification of the key parameter (not irritating to the rabbit skin) is based on results of the study Shell Development Company (1980A) / key (rabbit skin irritation) considered to be fully reliable and compliant to OECD TG 404 by the SIDS INITIAL ASSESSMENT REPORT For SIAM 18 - 1,2,3-Trichloropropane as at 2004. The result is backed up by a similar rated and study (Monsanto Company (1985A) / (rabbit, skin irritation)).
Both studies agree that there is some slight intermittent irritancy caused by 1,2,3-trichloropropane that is also reversible within 72 h in the former and within 10 at the latest in the latter study. In the former study overall PII was 1.63, while individual scores ranged from 1-2.5 in intact skin, and from 1-3 in abraded skin sites.In the latter study our-hour erythema scores reached a high of 2, clear by day 7 to 10; 4-hour edema scores were generally 1, clear by 72 hours. Twenty-four-hour erythema scores were 2, clear by day 7 to 10; 24-hour edema scores were 1, clear by day 7.
The differing results from Clark 1977, reporting skin irritancy after application of 1,2,3-trichloropropane to the rabbit skin are very likely due to the relative high amount of unknown impurities (8 %). Due to the lack of information on the nature of these impurities the study is deemed unreliable.
Therefore 1,2,3 -trichloropropane is deemed not to be a skin irritant which is in-line with the current classification and labelling.

- eye irritation: The classification of the key parameter (irritation to the rabbit eye) is based on the results of the study Shell Development Company (1980B) / key (rabbit eye irritation) considered to be fully reliable and compliant to OECD TG 405 by the SIDS INITIAL ASSESSMENT REPORT For SIAM 18 - 1,2,3-Trichloropropane as at 2004. The results are backed up by a similar rated and study (Monsanto Company (1985B) / (rabbit, eye irritation)). Both studies agree that 1,2,3-trichloropropane is slightly irritating to the rabbit eye, the former reportinga maximum overall irritation score of 20/110 for unwashed eyes, and 16.3/110 for washed eyes. The latter study states maximal chemosis scores of 1-3, cornea scores of 2, iris scores of 1 and conjuctivae scores of 1, which are all completely reversible between 3 and 7 days. The presented values are relatively low and might have supported a non-classification for eye irritation. But as individual data is not available and following a conservative approach, 1,2,3-trichloropropane is deemed irritating to the eye.
The differing results from Clark 1977, reporting slight eye irritancy after application of 1,2,3-trichloropropane to the rabbit eye are very likely due to the relative high amount of unknown impurities (8 %). Due to the lack of information on the nature of these impurities the study is deemed unreliable.

- respiratory irritation: no study available.


Effects on eye irritation: irritating

Justification for classification or non-classification

- skin irritation: Based on the above stated results 1,2,3-trichloropropane is deemed not to be irritating to the skin according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL).

- eye irritation: Based on the above stated results 1,2,3-trichloropropane is deemed irritating to the eye Category 2 (Warning, H319: Causes serious eye irritation) according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL).

- respiratory irritation: No study available