Registration Dossier
Registration Dossier
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EC number: 260-982-3 | CAS number: 57843-53-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
There was no inhibitory effect on sewage sludge bacteria up to the concentration of 55.7 mg/l. Thus, the concentration 55.7 mg/l can be selected to estimate the PNECSTP.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 55.7 mg/L
- EC10 or NOEC for microorganisms:
- 55.7 mg/L
Additional information
In the test report assessing the biodegradability (OECD 301 F) of N,N,N',N'-tetrakis(2-hydroxypropyl) hexanediamide, the toxicity control showed no inhibitory effect to the biodegradation of the test substance up to the substance concentration of 55.7 mg/l. Therefore, no microorganism toxicity was seen and according to the REACH guidance of “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance”, no further test for the substance need to be conducted to evaluate the respiration inhibition of active sludge. The concentration used in the toxicity control (55.7 mg/l) can be selected to estimate the PNECSTP.
Absence of toxicity to microorganisms is also supported by the results with the structurally similar substance N,N,N',N'-tetrakis(2-hydroxyethyl) hexanediamide in an OECD 209 study, in which sludge microorganisms were exposed to 1000 mg/L for three hours. No inhibition was observed and thus, the EC50 was determined as >1000 mg/L with the surrogate substance.
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