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EC number: 260-982-3 | CAS number: 57843-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 12 February and 30 March 2012.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Remarks:
- Using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
- Water solubility:
- > 612 g/L
- Temp.:
- 20 °C
- pH:
- >= 0.3 - <= 9.4
- Remarks on result:
- other: The water solubility of the test item has been determined to be greater than 612 g/L of solution at 20.0 ± 0.5 °C, the solubility showed loading rate dependence.
- Conclusions:
- The test substance is very soluble (> 10000 mg/L). The water solubility of the test item has been determined to be greater than 612 g/L of solution at 20.0 ± 0.5 °C, the solubility showed loading rate dependence.
- Executive summary:
The determination was carried out using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
By this method, the water solubility of the test item has been determined to be greater than 612 g/L of solution at 20.0 ± 0.5 °C, and the solubility showed loading rate dependence.
Reference
Results in Preliminary test
The analysed result from the preliminary estimate of water solubility was 541 g/L at 20 °C.
The results of the visual solubilities are shown in the following table.
Table 3.15
Mass of Test Item |
Quantity of water |
Concentration |
Observations |
0.1014 |
100 mL |
1.01 x 10³ mg/L |
Colourless solution with some particles suspended |
0.1052 |
10 mL |
1.05 x 10⁴ mg/L |
Colourless solution with some particles suspended |
0.5037 |
10 mL |
5.04 x 10⁴ mg/L |
Colourless solution with some particles suspended |
0.5068 |
2.0292 g |
20.0 % w/w |
Some particles in suspension |
0.5070 |
1.5310 g |
24.9 % w/w |
Clear colourless solution. Only a few particles in suspension |
1.0917 |
1.0157 g |
51.8 % w/w |
White cloudy solution |
1.5056 |
0.5069 g |
74.8 % w/w |
White paste |
1.8052 |
0.2268 g |
88.8 % w/w |
Test item appearance hardly changed |
Overall result: Solubility is less than 1.01 x 10³
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 3.16
Solution |
Mean Peak Area |
Standard at 502 mg/L |
1.88 x 10⁸ |
Standard at 505 mg/L |
1.88 x 10⁸ |
Matrix blank |
none detected |
Sample 1A |
2.27 x 10⁸ |
Sample 1B |
2.31 x 10⁸ |
Sample 2A |
2.26 x 10⁸ |
Sample 2B |
2.29 x 10⁸ |
Sample 3A |
2.30 x 10⁸ |
Sample 3B |
2.31 x 10⁸ |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Table 3.17
Sample Number |
Time Shaken at |
Time Equilibrated at 20 °C (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 ¼ |
24 |
612 |
9.40 |
2 |
48 ¼ |
24 |
608 |
9.37 |
3 |
72 ¼ |
24 |
615 |
9.35 |
Mean concentration: 612 g/L at 20.0 ± 0.5 °C Range: 608 to 615 g/L
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 101 to 1.01 x 10³ mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.
Description of key information
The water solubility of the test item has been determined to be greater than 612 g/L of solution at 20.0 ± 0.5 °C, and the solubility showed loading rate dependence.
Key value for chemical safety assessment
- Water solubility:
- 612 g/L
- at the temperature of:
- 20 °C
Additional information
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