Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Additional information

Data from Ames-tests only have been provided, since coal-tar pitch is classified as mutagenic and carcinogenic. In one of the tests, coal tar pitch (fume condensate) was used as supporting substance.

Tars and pitches constitute a family of products that result from different distillation steps of coal (condensation products and distillation residues). Depending on distillation step and distillation temperature, constituents of the products and their portions are variable. But major components of all the distillation products and residues are condensed ring aromatic hydrocarbons in varying composition (i.e. polynuclear aromatic hydrocarbons). Major toxicological effects of these products will primarily be caused by the PAH fraction in the respective substances. Especially for toxicological endpoints that fall into the toxicological action profile of PAH, it is justified to use related tars and pitches as supporting substances to characterise potential effects of pitch, coal tar, high temp.

Short description of key information:
Bacterial assays with coal-tar pitch or surrogates are positive (Ames).

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

Pitch, coal tar, high temp. contains BaP in concentrations up to 1.5%. BaP is known to be mutagenic and is classified as mutagenic Cat. 1B. In Ames tests, coal tar pitch, high temp. was demonstrated to be mutagenic. Based on BaP content, pitch, coal tar, high temp. is classified as mutagenic Cat 1B by the registrant.