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EC number: 266-028-2
CAS number: 65996-93-2
The residue from the distillation of high temperature coal tar. A black solid with an approximate softening point from 30°C to 180°C (86°F to 356°F). Composed primarily of a complex mixture of three or more membered condensed ring aromatic hydrocarbons.
The experimental observations of liver
degeneration resembled the historical fatal cases of young pigs grazing
on farmland, while adult pigs obviously remained unaffected.
Outbreaks of coal tar pitch poisoning in
grazing swine and pigs resulting in mortality and histological liver
changes, reported in the 1920s and 1930s, instigated experiments in
which groups of 9-week-old pigs were orally (diet and/or capsule) given
powdered clay pigeon remnants (consisting of CTP, finely ground
limestone, calcimine), powdered clay pigeon plus lead, or commercial CTP
(not further specified, no results data). Two additional groups given
lead and a normal diet, respectively, were included.
In the first group (n=5) given a total dose
of 57 g powdered remnants during five subsequent days, all animals died
within eight to 20 days. At autopsy, jaundice, excessive serous fluid in
the abdomen, oedematous visceral lymph nodes, and marked degenerative
liver changes were found in four out of five
animals. In the remaining fifth animal, there were no gross liver
Treatment with a total dose of 57 g of
powdered remnants together with a total dose of 25 g of lead (exposure
period: 5 days) caused the death of four out of five animals within 22
days. At autopsy, animals showed hepatic lesions. No such lesions were
seen in the surviving animal sacrificed after 60 days.
In the last experimental group, liquid coal
tar was administered by capsule at doses of 3 g/day, for five (n=3) or
two (n=2) days. All three animals dosed for five days died within 10 to
18 days showing diffuse degenerative changes in the liver. One of the
pigs dosed for two days died (at day 38). At autopsy, there were no
gross liver lesions, but pseudomelanosis of the entire colon was seen.
In the remaining animal sacrificed after 60
days, an extensive moist, proliferative dermatitis of unknown origin,
but no liver changes were reported. No gross pathology changes were seen
in the diet-control group. In the animals given lead alone, one out of
five animals died within 30 days showing a marked haemorrhagic
gastritis. No gross lesions were reported in the surviving animals
(according to NL 2009: Annex V transition
dossier on coal-tar pitch).
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