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EC number: 266-028-2
CAS number: 65996-93-2
The residue from the distillation of high temperature coal tar. A black solid with an approximate softening point from 30°C to 180°C (86°F to 356°F). Composed primarily of a complex mixture of three or more membered condensed ring aromatic hydrocarbons.
Initial absorption rates of 10 PAHs from
coal tar applied to the perfused pig ear
Absorption fluxes at 200 min p.a.
The mean absorption fluxes [pmol/(h*cm²)] at
200 min after application of coal tar varied strongly between the 10 PAH.
Furthermore, variation between ears was high,
too: for pyrene, for example, the flux ranged between 6 and 155
pmol/(h*cm²) and the cumulative uptake after 200 min was between 26 and
193 pmol/cm². This was not caused by differences in dosing: applied
amounts were high overdoses, because 0.2 % of each PAH was absorbed
through the skin after 200 min.
The relative cumulative uptake (in relation
to pyrene) was 0.01 for indeno[123-cd]pyrene to 12 for phenanthrene, for
each PAH except fluoranthene, statistically different from pyrene uptake
(p= 0.01). The inter-ear variation was relatively small when the
absorbed amount was related to pyrene, indicating that the relative
absorption fluxes of the various PAH were quite constant.
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