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EC number: 215-691-6
CAS number: 1344-28-1
The goal of
study is to assess the developmental toxicity and
embryotoxic/teratogenic potential of high doses of target compound -
AI(OH)3orally administered to rats during the period of
significant general/maternal toxicity was observed in any Al treated
groups that were orally exposed to Al hydroxide at doses 66.5, 133 and
266 mg Al/kg bw/day.
have contributed to the weight of evidence on the lack of pre-natal
developmental toxicity of Al hydroxide administered orally to rats at
high doses (66.6; 133 and 266 mg Al/kg bw/day). Toxicokinetic studies
support the reported negative developmental outcomes.
designed and conducted study with many studied endpoints comparable to
guideline OECD TG 414 with acceptable deviations.
particular test data/relevant information are absent (physiochemical
properties, identification including CAS number, details on food and
water quality (Al content in diet, water); details on test substance
formulations (preparation, pH, stability and homogeneity of the
preparation), details on reported negative teratogenic effects are not
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