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EC number: 215-691-6
CAS number: 1344-28-1
et al. (2008) studied
allergic inflammation after intratracheal instillation of Asian sand
dust,sand dust, amorphous silica and Al2O3in
6-week old male ICR mice. Four instillations were performed at 2-week
intervals. There were ten groups of animals (n=16 in each). One of these
groups received Al2O3(particle size 1~5
µm), a dose of 0.1 mg suspended in saline. The control group received
saline only (0.1 mL). The animals were killed one day after the last
instillation. Eight out of 16 animals in each group were used for
pathologic examination. The lung samples were stained with haematoxylin
and eosin to evaluate the degree of infiltration of eosinophils or
lymphocytes in the airways, and with periodic acid-shiff to evaluate the
degree of proliferation of goblet cells in the bronchial epithelium. The
other 8 mice were used for examination of free cell counts (total and
differential), determination of levels of lactate dehydrogenase (LDH),
cytokines (Interleukins – IL-5, IL-6, IL-12, IL-13, interferon-IFN-gand
tumor necrosis factor- TNF-a)
and chemokines in bronchoalveolar lavage fluids (BALF), and also total
IgE in serum using enzyme-linked immunosorbent assays (ELISA). In the
group of mice exposed to Al2O3, the levels of
eosinophil and lymphocyte infiltration in the submucosa and
proliferation of goblet cells in the airways, the level of LDH,
chemokines and interleukins, number of cells in BALF and the level of
IgE in serum were not significantly different from those in the control
mice. The results suggest that intratracheal administration of Al2O3does
not produce allergic inflammatory effects in the lungs of mice.
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