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EC number: 215-691-6
CAS number: 1344-28-1
Test groups (8
After the challenge
dose of AK 43/79, all animals from this group developed a mild skin
The challenge dose of
AK 44/79 provoked mild reaction in 6 animals and moderate reaction in 2
Control group (8
AK 43/79 (controls)
After the challenge
dose of AK 43/79, the control animals showed a mild reaction in 7 and a
moderate reaction in 1 animal.
AK 44/79 (controls)
The challenge dose of
AK 44/79 provoked 7 mild reactions and 1 moderate reaction.
significant differences were reported between both test compounds and
the control animals with respect to the degree and incidence of erythema
Individual data are
provided in Table 1 and 2 of the report.
Table 1. Individual
positive reactions (marked with + signs) observed during the induction
and challenge period with AK 43/79
Individual direct reaction
Reaction to injection at the same time as the challenge
Degree of reaction: + = mild; ++ = moderate
The skin sensitisation
potential of two samples aluminium oxide, namely aluminium oxide TBH: AK
43/79 and aluminium oxide TOF: AK 44/79, was assessed in guinea pigs
(male albino SPF, 8 animals in each group) using the Landsteiner/Draize
method (Central Institute for Nutrition and Food Research, Germany) at
the request of Degussa AG, Germany (1979). Both compounds were
administered by intra-dermal injections. A 33.3% aqueous suspension was
used in both the induction and challenge phases. During the induction
phase, the test animals received 10 intra-dermal injections of the test
suspension, 3 times per week over a 3 week period. The
test suspensions were administered to different shaved spots on the
right flank of the animals within an area of 3 x 4 cm. The injected
volume was 0.05 mL for the first injection and 1.0 mL for subsequent.
The control group received a single injection during this phase. The
injection sites were examined 24 hours after the injection and the
diameter, colour and thickness of any lesions were used as criteria for
the intensity of the reaction. In the induction phase,following
1 to 7 injections of AK 43/79, all animals showed mild reactions. Two
animals showed moderate reactions after the 8th injection, an
additional 2 animals showed moderate reactions after the 9th injection
and all 8 animals showed a moderate reaction after the 10th injection.
Data were provided on any skin reactions on the single injection
received by the control animals. For AK 44/79, all reactions were mild
until after the 6th injection when 5 animals showed a
moderate reaction. All animals showed moderate reactions
after the 7th to
10th injections. Two
weeks after the last injection, guinea pigs from both test groups and
the control group received the challenge dose in the amount of 0.05 mL
per animal. The reaction sites were examined 24 hours after the
the challenge dose of AK 43/79, all animals exposed during the induction
period developed a mild skin reaction. A mild reaction was also found in
7 and a moderate reaction in 1 of the animals in the control group. The
challenge dose of AK 44/79 provoked a mild reaction in 6 animals and
moderate reaction in 2 animals exposed during the induction period. In
the control animals, 7 mild reactions and 1 moderate reaction were
observed. No significant differences were observed between the test and
control animals with respect to the degree and incidence of erythema and
oedema. Under the conditions of this test, aluminium oxide
AK 43/79 and aluminium oxide AK 44/79 are not skin sensitizers
(Landsteiner/Draize test, guinea pig).
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