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Particle size distribution (Granulometry)

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Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not provided
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data provided, but no report or supporting information on test procedures provided
Qualifier:
equivalent or similar to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
GLP compliance:
not specified
Type of method:
Laser scattering/diffraction
Percentile:
D50
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
No.:
#1
Size:
> 200 µm
Remarks on result:
other: None of the particles in any sample were greater than 200 µm
No.:
#2
Size:
< 100 µm
Remarks on result:
other: 98-100% of coarse gound alumina; 64-96% of fine unground alumina; and 100% of fine ground alumina
No.:
#3
Size:
< 2 µm
Remarks on result:
other: 11-13% of coarse ground alumina; 1-1.5% of fine unground alumina; and 92-93% of fine ground alumina
Conclusions:
The proportion of test material having an inhalable particle size less than 100 µm was determined to be 98-100% for the coarse ground alumina, 64-96% for the fine unground alumina, and 100% for the fine ground alumina. The proportion of test material having a respirable particle size less than 2 µm was determined to be 11-13% for the coarse ground alumina, 1-1.5% for the fine unground alumina, and 92-93% for the fine ground alumina.
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientific study of presence of aluminium fibres within a number of individuals with previous occupational exposure in the aluminium industry. Study results presented in peer reviewed journal.
Principles of method if other than guideline:
Numeral concentration of fibrous mineral particles containing only aluminium and their granulometry were determined in bronchoalveolar fluid and lung tissue.
Percentile:
other:
Remarks on result:
other: The dimensions of the fibres are reported.

Respirable fraction fibres - 0.85 x 0.2 microns (from bronchoalveolar lavage fluid, n=2)

Thoracic fraction fibres - 3.7 x 0.8 microns (from lung tissue, n=2)

Executive summary:

The size of aluminium fibres ranges from 0.85 x 0.2 microns to 3.7 x 0.8 microns

Description of key information

Particle size distribution studies conducted with Malvern laser and sedigraph. 

Additional information

Particle size distributions ranged from 0.1 - 150 µm for coarse ground alumina, 0.15 - 250 µm for fine unground alumina, and 0.125 - 40 um for fine ground alumina.