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EC number: 212-110-8
CAS number: 763-32-6
This study was designed to evaluate
the potential toxic effects of the test item Isoprenol (IPN) when
administered to rats for a minimum of 28 days and to evaluate the
potential of the test item to affect male and female reproductive
performance such as gonadal function, mating behavior, conception,
parturition, and early postnatal development.
slight non-significant prolongation of pre-coital interval was observed
in the 450 mg/kg bw/day dose group. There were no test item-related
effects on other parameters of F0 reproductive performance, gestation
length, parturition, or reproductive organs at any dosage level. Also,
there were no changes in a mean number of pups born, live litter size,
and postnatal survival. However, the body weight of newborn females (and
less in males) was reduced in the 450 mg/kg bw/day dose group; and
normalized anogenital distance was slightly non-significantly decreased
in females as well as males newborns. The slight increase in the
percentage of newborn males was noted in litters in the 150 and 450
mg/kg bw/day dose groups. The
number of F1 males with retention of areolae on PND 13 was slightly
non-significantly increased compared to the control group and historical
Therefore, under the conditions of this
screening study, the no-observed-adverse-effect-level (NOAEL) was 50
mg/kg bw/day for F1 developmental toxicity.
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