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EC number: 212-110-8
CAS number: 763-32-6
SKIN IRRITATION:not irritating to the skin (BASF, 1968)EYE IRRITATION:risk of serious damage to the eyes (BASF, 1968)RESPIRATORY IRRITATION:No data are available.
Table: Skin findings and scores (converted to Draize system)
Findings at 24 h
Findings at 8 d
Animal no. 1
Animal no. 2
at any treated
Table: Findings and scores (converted to Draize system)
brown colouration of the mucosa
bleeding and brown colouration of the mucosa
mucosal bleeding, vascularization, staphyloma
In a primary dermal irritation study (BASF, 1968), 2 Vienna
White rabbits were dermally exposed to unchanged 3-methyl-3-buten-1-ol
(99% pure) for 1, 5, and 15 minutes. Two further Vienna White rabbits
were dermally exposed to 3-methyl-3-buten-1-ol (99% pure) for 20
hours. All applications were made under occlusive conditions to a
dorsal skin area of 2.5 cm x 2.5 cm in size. Animals then were
observed for 8 days. Irritation was scored by an internal method; the
scores are convertible to Draize scores.
Signs of irritation were limited to slight erythema (Draize
score 1) observed at 24 h at each site with exception of the dorsal
site exposed for one minute. All test sites were normal by day 8. In
this study, 3-methyl-3-buten1-ol is minimally irritating to the skin;
labeling is not required.
In a primary eye irritation study (BASF, 1968), 50 µl of
unchanged 3-methyl-3-buten-1-ol (99% pure) was instilled into the
conjunctival sac of the right eye of 2 Vienna White rabbits without
rinsing. For control purpose, saline was instilled into the left eye
of each rabbit. Animals then were observed for 8 days. Irritation was
scored by an internal method; the scores are convertible to Draize
Marked to strong corneal opacity, conjunctivae redness,
chemosis, and iritis, were reported and persisted at the end of the
8-day observation. Furthermore, mucosal bleeding and vascularization
were observed. In this study, 3-methyl-3-buten-1ol is severely
irritating to the eye based on persisting corneal opacity and iritis.
No data are available.
Effects on eye irritation: corrosive
There is no need to classify 3-methyl-3-buten-1-ol for skin
irritation according to the Directive 67/548/EC or GHS criteria.
Based on persisting corneal opacity and iritis observed at 8
days after instillation, 3-methyl-3-buten-1-ol has to be classified as
“risk of serious damage to the eyes” according to the Directive
67/548/EC. According to the GHS criteria, 3 -methyl-3 -buten-1 -ol has
to be classified as follows: Cat. 1 (irreversible effects on the eye).
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