Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-110-8
CAS number: 763-32-6
SKIN IRRITATION:not irritating to the skin (BASF, 1968)EYE IRRITATION:risk of serious damage to the eyes (BASF, 1968)RESPIRATORY IRRITATION:No data are available.
Table: Skin findings and scores (converted to Draize system)
Findings at 24 h
Findings at 8 d
Animal no. 1
Animal no. 2
at any treated
Table: Findings and scores (converted to Draize system)
brown colouration of the mucosa
bleeding and brown colouration of the mucosa
mucosal bleeding, vascularization, staphyloma
In a primary dermal irritation study (BASF, 1968), 2 Vienna
White rabbits were dermally exposed to unchanged 3-methyl-3-buten-1-ol
(99% pure) for 1, 5, and 15 minutes. Two further Vienna White rabbits
were dermally exposed to 3-methyl-3-buten-1-ol (99% pure) for 20
hours. All applications were made under occlusive conditions to a
dorsal skin area of 2.5 cm x 2.5 cm in size. Animals then were
observed for 8 days. Irritation was scored by an internal method; the
scores are convertible to Draize scores.
Signs of irritation were limited to slight erythema (Draize
score 1) observed at 24 h at each site with exception of the dorsal
site exposed for one minute. All test sites were normal by day 8. In
this study, 3-methyl-3-buten1-ol is minimally irritating to the skin;
labeling is not required.
In a primary eye irritation study (BASF, 1968), 50 µl of
unchanged 3-methyl-3-buten-1-ol (99% pure) was instilled into the
conjunctival sac of the right eye of 2 Vienna White rabbits without
rinsing. For control purpose, saline was instilled into the left eye
of each rabbit. Animals then were observed for 8 days. Irritation was
scored by an internal method; the scores are convertible to Draize
Marked to strong corneal opacity, conjunctivae redness,
chemosis, and iritis, were reported and persisted at the end of the
8-day observation. Furthermore, mucosal bleeding and vascularization
were observed. In this study, 3-methyl-3-buten-1ol is severely
irritating to the eye based on persisting corneal opacity and iritis.
No data are available.
Effects on eye irritation: corrosive
There is no need to classify 3-methyl-3-buten-1-ol for skin
irritation according to the Directive 67/548/EC or GHS criteria.
Based on persisting corneal opacity and iritis observed at 8
days after instillation, 3-methyl-3-buten-1-ol has to be classified as
“risk of serious damage to the eyes” according to the Directive
67/548/EC. According to the GHS criteria, 3 -methyl-3 -buten-1 -ol has
to be classified as follows: Cat. 1 (irreversible effects on the eye).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again