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Key value for chemical safety assessment

Additional information


In a reverse gene mutation assay in bacteria (BASF 1989), strains  TA1535, TA1537, TA98 and TA100 of S. typhimurium were exposed to 3-methyl-3-buten-1-ol (99% pure) in DMSO at concentrations of 0, 20, 100, 500, 2500, and 5000 µg/plate in the presence and absence of mammalian metabolic activation (Standard plate test and Preincubation test).

3-Methyl-3-buten-1-ol was tested up to cytotoxic concentrations. The positive controls induced the appropriate responses in the corresponding strains. There was no evidence of induced mutant colonies over background.

This study is classified as acceptable. This study satisfies the requirement for Test Guideline OECD 471 for in vitro mutagenicity (bacterial reverse gene mutation) data.


No data are available.

Short description of key information:
Not mutagenic in a bacterial reverse mutation test (Ames test) (BASF, 1989)

No data are available.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

There is no need to classify 3-methyl-3-buten-1-ol for mutagenicity according to the Directive 67/548/EC or GHS criteria.