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EC number: 212-110-8
CAS number: 763-32-6
This study was performed to investigate the potential of Isoprenol to
induce micronuclei in polychromatic erythrocytes (PCE) in the bone
marrow of the mouse.
The test item was formulated in corn oil, which was also used as vehicle
control. The volume administered orally was 10 mLlkg b.w.. 24 hand 48 h
after a single administration of the test item the bone marrow cells
were collected for micronuclei analysis.
Seven males per test group (except the vehicle and positive control
groups with 5 males each) were evaluated for the occurrence of
micronuclei. Per animal 2000 polychromatic erythrocytes (PCEs) were
scored for micronuclei.
To describe a cytotoxic effect due to the treatment with the test item
the ratio between polychromatic and normochromatic erythrocytes was
determined in the same sample and reported as the number of PCEs per
After treatment with the test item the number of PCEs was not
substantially decreased as compared to the mean value of PCEs of the
vehicle control thus indicating that Isoprenol
did not exert any cytotoxic effects in the bone marrow. In comparison to
the corresponding vehicle controls there was no biologically relevant or
statistically significant enhancement in the frequency of the detected
micronuclei at any preparation interval after administration of the test
item and with any dose level used. Cyclophosphamide as positive control
showed a substantial increase of induced micronucleus frequency.
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