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EC number: 212-110-8
CAS number: 763-32-6
The study was performed to investigate the potential of Isoprenol to
induce gene mutations at the HPRT locus in V79 cells of the Chinese
The assay was performed in two independent experiments, using two
parallel cultures each. The first main experiment was performed with and
without liver microsomal activation and a
treatment period of 4 hours. The second experiment was performed with a
treatment time of 4 hours with and 24 hours without metabolic activation.
The highest concentration of the test item (880 μg/mL) was equal to a
molar concentration of about 10 mM.
The tested concentrations are described in Table 2 (page 19). The
evaluated experimental points and the results are summarised in Table 1
No substantial and reproducible dose dependent increase of the mutation
frequency was observed in both main experiments.
Appropriate reference mutagens, used as positive controls, induced a
distinct increase in mutant colonies and thus, showed the sensitivity of
the test item and the activity of the metabolic activation system.
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