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EC number: 212-110-8 | CAS number: 763-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1698-10-29 and 1968-11-058
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment; pre-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF Test (internal standard procedure). In principle, the methods described by OECD TG 401 were used.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methylbut-3-en-1-ol
- EC Number:
- 212-110-8
- EC Name:
- 3-methylbut-3-en-1-ol
- Cas Number:
- 763-32-6
- Molecular formula:
- C5H10O
- IUPAC Name:
- 3-methylbut-3-en-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-methyl-3-buten-1-ol
- Analytical purity: 99%
No further data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male and female Sprague-Dawley rats
- Source: Gassner
- Weight at study initiation: body weight range: males: 138 - 190 g; females: 124 - 158 g
No further data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Traganth (emulsion)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 - 30 % (v/v) - Doses:
- ca. 170, 1360, 2720, 5440 mg/kg bw (200, 1600, 3200, 6400 ml/kg bw)
- No. of animals per sex per dose:
- 10 males and 10 females per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Group-wise documentation of clinical signs was performed over the 7-day observation period. Body weight was determined before the study only, as it was needed for determination of the dose.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 440 mg/kg bw
- Mortality:
- Four out of 20 rats of group 1 (6400 ml/kg) died; total mortality rate was 2/20, 3/20, and 4/20 by 24 h, 48 h and 7 days post dose, respectively. No deaths were observed at lower doses. See also Table 2.
- Clinical signs:
- other: Clinical symptoms were observed in all dose groups; incidence and severity showed a trend to dose-relationship. Clinical symptoms comprised marked staggering, prone/lateral position with extended extremities, narcosis-like state, dyspnea, chewing movement
- Gross pathology:
- Pathology of the decedents revealed distended gastro-intestinal tract (1 animal), possible renal changes (1 animal), and putrefaction. Signs of cannibalism were noted for 2 animals.
No pathologic findings were noted in survivors that had been sacrificed at the end of the observation period.
Any other information on results incl. tables
Table 2: mortality
group |
number of animals |
concentration in vehicle [% (v/v)] |
applied dose |
mortality rate within |
||||
[ml/kg bw |
[mg/kg bw] |
1 h |
24 h |
48 h |
7 d |
|||
1 |
20 |
30 |
6400 |
5440 |
0/20 |
2/20 |
3/20 |
4/20 |
2 |
20 |
30 |
3200 |
2720 |
0/20 |
0/20 |
0/20 |
0/20 |
3 |
20 |
20 |
1600 |
1360 |
0/20 |
0/20 |
0/20 |
0/20 |
4 |
20 |
2 |
200 |
170 |
0/20 |
0/20 |
0/20 |
0/20 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- 3-Methyl-3-buten-1-ol was practically nontoxic in rats after ingestion.
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