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EC number: 212-110-8 | CAS number: 763-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
ORAL
LD50, rat > 5440 mg/kg bw (BASF, 1968)
DERMAL
No data are available.
INHALATION
No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound. The nominal concentration of the test substance was 21.5 mg/l. (BASF, 1968)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1698-10-29 and 1968-11-058
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment; pre-GLP study.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF Test (internal standard procedure). In principle, the methods described by OECD TG 401 were used.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male and female Sprague-Dawley rats
- Source: Gassner
- Weight at study initiation: body weight range: males: 138 - 190 g; females: 124 - 158 g
No further data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data - Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Traganth (emulsion)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 - 30 % (v/v) - Doses:
- ca. 170, 1360, 2720, 5440 mg/kg bw (200, 1600, 3200, 6400 ml/kg bw)
- No. of animals per sex per dose:
- 10 males and 10 females per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Group-wise documentation of clinical signs was performed over the 7-day observation period. Body weight was determined before the study only, as it was needed for determination of the dose.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- no data
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 440 mg/kg bw
- Mortality:
- Four out of 20 rats of group 1 (6400 ml/kg) died; total mortality rate was 2/20, 3/20, and 4/20 by 24 h, 48 h and 7 days post dose, respectively. No deaths were observed at lower doses. See also Table 2.
- Clinical signs:
- other: Clinical symptoms were observed in all dose groups; incidence and severity showed a trend to dose-relationship. Clinical symptoms comprised marked staggering, prone/lateral position with extended extremities, narcosis-like state, dyspnea, chewing movement
- Gross pathology:
- Pathology of the decedents revealed distended gastro-intestinal tract (1 animal), possible renal changes (1 animal), and putrefaction. Signs of cannibalism were noted for 2 animals.
No pathologic findings were noted in survivors that had been sacrificed at the end of the observation period. - Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- 3-Methyl-3-buten-1-ol was practically nontoxic in rats after ingestion.
Reference
Table 2: mortality
group |
number of animals |
concentration in vehicle [% (v/v)] |
applied dose |
mortality rate within |
||||
[ml/kg bw |
[mg/kg bw] |
1 h |
24 h |
48 h |
7 d |
|||
1 |
20 |
30 |
6400 |
5440 |
0/20 |
2/20 |
3/20 |
4/20 |
2 |
20 |
30 |
3200 |
2720 |
0/20 |
0/20 |
0/20 |
0/20 |
3 |
20 |
20 |
1600 |
1360 |
0/20 |
0/20 |
0/20 |
0/20 |
4 |
20 |
2 |
200 |
170 |
0/20 |
0/20 |
0/20 |
0/20 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 440 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1968-09-24 (day of exposure)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment; pre-GLP study.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- BASF Test (internal standard procedure). In principle, the methods described by OECD TG 403 were used.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- other: Inhalation Risk Test
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further data
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- This test was in principle performed as described in OECD Guideline 403.
- Temperature chosen for vapour generation: 20°C.
GENERAL PROCEDURE
Two groups of 3 rats per sex were exposed sequentially to the vapours by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods (e.g. 3 min, 10 min, 1 h, 3 h, 7 h or 8 h). The exposure time not causing lethality was usually tested twice.
No analytical determination of the atmosphere concentration was performed. The nominal concentration can be calculated as quotient of the amount of test substance weight loss during the exposure (given in the raw data) and the amount of air used during exposure. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- 21.5 mg/l (atmosphere saturated with vapour)
- No. of animals per sex per dose:
- totally 12 rats (6 males, 6 females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Groupwise documentation of clinical signs was performed over the 7-day observation period. Body weight of groups was determined before the start of exposure and at the end of the observation period in surviving animals.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Key result
- Sex:
- male/female
- Dose descriptor:
- LCLo
- Effect level:
- > 21.5 mg/L air (nominal)
- Exp. duration:
- 8 h
- Remarks on result:
- other: No deaths at saturated vapour concentration.
- Mortality:
- All animals survived until the end of the 7-day observation period.
- Clinical signs:
- other: Irritation of the mucosa and dyspnea was observed during exposure. After termination of exposure, imbalance and, for one animal, narcosis was noted. The animals were normal at one day after exposure.
- Gross pathology:
- Chronic bronchitis was reported for two animals. No pathological findings were observed in the remaining 10 animals.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Conclusions:
- No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound. The concentration of the test substance was 21.5 mg/l (nominal).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
ORAL
In an acute oral toxicity study (BASF 1968), groups of young Sprague-Dawley rats (10/sex) were given a single oral dose of 3 -methyl-3-buten-1-ol (99% pure, emulsified in aqueous Traganth), at doses of ca. 170, 1360, 2720, 5440 mg/kg bw (200, 1600, 3200, 6400 ml/kg bw) and observed for 7 days.
Oral LD50Combined > 5440 mg/kg bw, the highest dose applied
3-Methyl-3-buten-1-ol is of LOW Toxicity based on the LD50in both sexes.
Four out of 20 rats of the highest dose group died; no other deaths were observed. Clinical symptoms were unspecific in nature, were noted at all dose levels and were reversible within 3 days. Pathology revealed changes of the gastrointestinal tract and renal changes in some decedents.
DERMAL
No data are available.
INHALATION
In an Inhalation Risk Test (BASF, 1968), totally 12 rats were exposed by inhalation route to an atmosphere that had been saturated at 20°C with the volatile parts of 3-methyl-3-buten-1-ol (99% pure) for up to 8 hours (nominal test concentration: 21.5 mg/l). Animals then were observed for 7 days.
No deaths occurred. Clinical symptoms were limited to irritation of the mucosa, dyspnea, imbalance and, in part, narcosis; animals were normal by day 1 post exposure. Gross pathology revealed chronic bronchitis for 2 individual animals.
3-Methyl-3-buten-1-olis classified as being of LOW Toxicity based on the lack of any adverse, specific observations under the conditions of this test.
Justification for classification or non-classification
There is no need to classify 3 -methyl-3-buten-1-ol for oral toxicity according to the Directive 67/548/EC or GHS criteria.
There is no need to classify 3 -methyl-3-buten-1-ol for acute inhalation toxicity according to the Directive 67/548/EC or GHS criteria.
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