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EC number: 212-110-8
CAS number: 763-32-6
ORAL LD50, rat > 5440 mg/kg bw (BASF, 1968)DERMAL No data are available.INHALATION No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound. The nominal concentration of the test substance was 21.5 mg/l. (BASF, 1968)
Table 2: mortality
mortality rate within
In an acute oral toxicity study (BASF 1968), groups of young
Sprague-Dawley rats (10/sex) were given a single oral dose of 3
-methyl-3-buten-1-ol (99% pure, emulsified in aqueous Traganth), at
doses of ca. 170, 1360, 2720, 5440 mg/kg bw (200, 1600, 3200, 6400
ml/kg bw) and observed for 7 days.
Oral LD50Combined > 5440 mg/kg bw,
the highest dose applied
3-Methyl-3-buten-1-ol is of LOW Toxicity based
on the LD50in both sexes.
Four out of 20 rats of the highest dose group died; no other
deaths were observed. Clinical symptoms were unspecific in nature,
were noted at all dose levels and were reversible within 3 days.
Pathology revealed changes of the gastrointestinal tract and renal
changes in some decedents.
No data are available.
In an Inhalation Risk Test (BASF, 1968), totally 12 rats were
exposed by inhalation route to an atmosphere that had been saturated
at 20°C with the volatile parts of 3-methyl-3-buten-1-ol (99% pure)
for up to 8 hours (nominal test concentration: 21.5 mg/l). Animals
then were observed for 7 days.
No deaths occurred. Clinical symptoms were limited to irritation
of the mucosa, dyspnea, imbalance and, in part, narcosis; animals were
normal by day 1 post exposure. Gross pathology revealed chronic
bronchitis for 2 individual animals.
3-Methyl-3-buten-1-olis classified as being of LOW Toxicity based
on the lack of any adverse, specific observations under the conditions
of this test.
There is no need to classify 3 -methyl-3-buten-1-ol for oral
toxicity according to the Directive 67/548/EC or GHS criteria.
There is no need to classify 3 -methyl-3-buten-1-ol for acute
inhalation toxicity according to the Directive 67/548/EC or GHS
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