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EC number: 203-398-6
CAS number: 106-44-5
Developmental toxicity study according to TSCA Health Effects Test
guidelines for Specific Organ/Tissue Toxicity - Developmental Toxicity
Administration of p-cresol by gavage to time-pregnant Sprague-Dawley
rats during organogenesis at 0.0, 30.0, 175.0,
or 450.0 mg/kg bw/d resulted in maternal toxicity at 450 mg/kg bw/d and
included mortality, clinical signs of toxicity ,
reduced weight gain and food consumption during dosing and reduced
gestational weight gain corrected for the gravid
uterus . Slight developmental toxicity was observed at 450 mg/kg bw/d
and included reduced ossification in three
skeletal districts in addition with reduced fetal body weight. Thus, The
NOAEL for maternal toxicity and
developmental toxicity is 175 mg/kg bw/d.
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