Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-398-6 | CAS number: 106-44-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: no guideline study: 1 hr exposure time
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio-Fax-data sheet: p-cresol
- Author:
- Industrial. Bio-Test Laboratory Inc.
- Year:
- 1 969
- Bibliographic source:
- Industrial Bio-Test Laboratory Inc, Northbrook, Ill/USA, data sheet no. 5-5/69
Materials and methods
- Principles of method if other than guideline:
- Exposure to the substance for 1 hr, room temperature, total air flow: 10.0 lpm. (no further information), up to 14 d post exposure observation, gross necropsy.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- p-cresol
- Details on test material:
- Test substance: p-cresol, purity not noted, M.P.:36°C, B.P.: 202°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- no further data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 0.71 mg/l
- No. of animals per sex per dose:
- 6 male rats
- Control animals:
- no
- Details on study design:
- no further data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.71 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: no mortality, no findings reported
- Mortality:
- no
- Clinical signs:
- other: no
- Body weight:
- initial mean body weight: 218g terminal mean body weight: 270 g
- Gross pathology:
- no findings
- Other findings:
- no further data
Any other information on results incl. tables
Applicant's summary and conclusion
- Executive summary:
Following exposure of rats against 0.71 mg/L p-cresol for 1 hour, no rat died and no clinical findings were reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
