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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: no guideline study: 1 hr exposure time

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax-data sheet: p-cresol
Author:
Industrial. Bio-Test Laboratory Inc.
Year:
1969
Bibliographic source:
Industrial Bio-Test Laboratory Inc, Northbrook, Ill/USA, data sheet no. 5-5/69

Materials and methods

Principles of method if other than guideline:
Method: other: exposure to the substance for 1 hr, room temperature, total air flow: 10.0 lpm. (no further information), up to 14 d post exposure observation, gross necropsy
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: p-cresol, purity not noted, M.P.:36°C, B.P.: 202°C

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
no further data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: air
Details on inhalation exposure:
no further data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 1 h
Concentrations:
0.71 mg/l
No. of animals per sex per dose:
6 male rats
Control animals:
no
Details on study design:
no further data
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 0.71 mg/L air
Exp. duration:
1 h
Remarks on result:
other: no mortality, no findings reported
Mortality:
no
Clinical signs:
no
Body weight:
initial mean body weight: 218g terminal mean body weight: 270 g
Gross pathology:
no findings
Other findings:
no further data

Any other information on results incl. tables

Mortality: 0/6; signs of intoxication: none; gross autopsy: no significant findings

Applicant's summary and conclusion

Executive summary:

Following exposure of rats against 0.71 mg/L p-cresol for 1 hour, no rat died and no clinical findings were reported.