Registration Dossier
Registration Dossier
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EC number: 203-398-6 | CAS number: 106-44-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: no guideline study: 1 hr exposure time
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio-Fax-data sheet: p-cresol
- Author:
- Industrial. Bio-Test Laboratory Inc.
- Year:
- 1 969
- Bibliographic source:
- Industrial Bio-Test Laboratory Inc, Northbrook, Ill/USA, data sheet no. 5-5/69
Materials and methods
- Principles of method if other than guideline:
- Exposure to the substance for 1 hr, room temperature, total air flow: 10.0 lpm. (no further information), up to 14 d post exposure observation, gross necropsy.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- p-cresol
- Details on test material:
- Test substance: p-cresol, purity not noted, M.P.:36°C, B.P.: 202°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- no further data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 0.71 mg/l
- No. of animals per sex per dose:
- 6 male rats
- Control animals:
- no
- Details on study design:
- no further data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.71 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: no mortality, no findings reported
- Mortality:
- no
- Clinical signs:
- other: no
- Body weight:
- initial mean body weight: 218g terminal mean body weight: 270 g
- Gross pathology:
- no findings
- Other findings:
- no further data
Any other information on results incl. tables
Applicant's summary and conclusion
- Executive summary:
Following exposure of rats against 0.71 mg/L p-cresol for 1 hour, no rat died and no clinical findings were reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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