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EC number: 203-398-6
CAS number: 106-44-5
Valid tests on acute toxicity to fish are available for 9 freshwater and
1 marine species.
The acute toxicity of p-cresol to fish was determined with a static
bioassay on several freshwater species. The highest toxicity is a 96h
LC50 value of 4.4 mg/L with Salmo trutta.
The chronic toxicity of p-cresol to fish was tested with Pimephales
promelas in an Early-Life Stage Toxicity Test equivalent to OECD
Guideline 210. The 32d NOEC is 1.35 mg/L.
The short term toxicity of p-cresol to freshwater invertebrates (Daphnia
magna) was measured according to German Guideline DIN 38412 part 11. The
EC50 (48 h) is 7.7 mg/L. The toxicity of p-cresol to the freshly
fertilized eggs of the marine sea urchin Strongylocentrotus
droebachiensis was determined by a static test. For p-cresol the EC50
(96 h) is 5 mg/L.
The long-term toxicity of p-cresol to aquatic invertebrates was
determined in a semi-static test according to the preliminary guideline
proposal of the German Umweltbundesamt from1984. After 21 days of
exposure a NOEC of 1 mg/l was determined.
Toxicity to aquatic algae and cyanobacteria:
The toxicity of p-cresol to the green algae Desmodesmus subspicatus
(former name Scenedesmus subspicatus) was determined according to DIN
38412 part 9 (draft standard for cell multiplication inhibition). Based
on nominal concentrations a 48 h-EC50 of 21 mg/l and an EC10 of 4.6 mg/l
(both related to growth rate) were determined.
Microbiological Activity in Sewage Treatment Systems:
The sensitivity of activated sludge to p-cresol was determined by a
respiration inhibition test according to OECD Guideline 209. The 2h IC50
for respiration inhibion of microorganisms is 440 mg/L. The effect of
p-cresol on Nitrosomonas activity was measured as a nitrification
inhibition method comparable to ISO/DIS 9509. The 24 h-IC50 was 27 mg/L.
For respiration, the 49 h-IC50 was 260 mg/L. Nitrification inhibition by
p-cresol was also measured by a similar method yielding an EC75 of 16.5
mg/L during a 2 -4 h incubation period. The EC50(48 h) with respect to
growth of Tetrahymena pyriformis accounts for 157 mg/L testing p-cresol.
Suspected Endocrine Properties of p-cresol:
The below mentioned data are not given as robust study summaries as
IUCLID does not supply relevant endpoint summaries. A literature survey
for endocrine properties of cresols in aquatic organisms was performed
in 2014. Relevant hits were chosen and assessed as follows:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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