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EC number: 203-398-6
CAS number: 106-44-5
There are no reliable experimental data on bioaccumulation for p-cresol available. Therefore, data of the isomer m-cresol and o-cresol are taken into account to describe the potential for bioaccumulation of p-cresol based on a read-across approach. The lowest value of 10.7 is used for assessment.
There are no reliable experimental data on bioaccumulation for p-cresol
available. Therefore, data of the isomer m-cresol and o-cresol are taken
into account to describe the potential for bioaccumulation of p-cresol.
Because of the similar log Kow values 1.95 for o-cresol, 1.96 m-cresol-
and 1.94 for p-cresol, a similar accumulation behaviour is expected. As
the experimentally determined BCF for o-cresol and m-cresol indicates a
low bioaccumulation potential, the potential for bioaccumulation of
p-cresol is also considered to be low.
Justification for the read-across approach:
Data from substances who’s physicochemical, toxicological and
ecotoxicological properties are likely to be similar or follow a regular
pattern as a result of structural similarity may be used in a
read-across approach in order to avoid unnecessary animal testing. It
can be stated that the 3 cresols act as a prime example of substances
that are suitable for read-across. Cresols are isomers and, thus ideally
fulfill the recommended criteria of structural similarity. In its
chemical structure, a cresol molecule has a methyl group substituted
onto the benzene ring of a phenol molecule, by different arrangement of
the -CH3 groups are three structural isomers possible. (ortho-cresol,
meta-cresol and para-cresol). Of particular importance to environmental
effects are the values for partition coefficient (log Kow), vapour
pressure, water solubility and dissociation constant. The values of the
isomers are very close together, resulting in the same environmental
fate and behaviour. Further, with regard to the bioderadation behavior,
all 3 cresols are readily biodegradable. Concerning aquatic toxicity of
the cresols on aquatic species, a large number of experimental results
from tests with fish, invertebrates and algae are available, indicating
a similar toxicity of all isomers, with p-cresol being slightly more
toxic in acute tests: Based on the similarities in the results mentioned
above the read-across approach is therefore scientifically justified.
The bioconcentration factor (BCF) in fish (Leuciscus idus melanotus) was
determined with 14C-labelled m-cresol. The fish were exposed to a 0.05
mg/l solution of the tests compound. After the test period of 3 days
radioactivity was measured in water medium and fish. A BCF value of 20
In a flow-through test according to OECD guideline 305 E for o-cresol a
BCF of 10.7 in zebrafish (Brachydanio rerio) were obtained and hence
o-cresol is not bioaccumulative.
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