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EC number: 203-398-6
CAS number: 106-44-5
The available data on avian toxicity cannot be used for assessment due to the insufficient documentation.In accordance with section 1 of REACH Annex XI, the study does not need to be conducted as avian toxicity data are used in the assessment of secondary poisoning which is required for substances indicating a bioaccumulation potential. p-Cresol has a low potential for bioaccumulation and no adverse effects to birds due to bioaccumulation in food chains would be expected.
No appropriate avian toxicology data are available for p-cresol. Avian
toxicity data are used in the assessment of secondary poisoning risks
for the aquatic and terrestrial food chains. Secondary poisoning
concerns the potential toxic impact of a substance on a predatory bird
or mammal following ingestion of prey items (i.e. fish and earthworms)
that contain the chemical. Accumulation of chemicals through the food
chain may follow many different pathways along different trophic levels.
As assessment is solely required for substances for which there is an
indication for bioaccumulation potential (ECHA, R.7c, 2008).
Bioconcentration factors (BCF) can be used for assessment. Based on the
experimental BCF value of the isomer m-cresol indicating no significant
potential for bioaccumulation in aquatic organisms, for p-cresol, a
similar bioaccumulation behaviour is expected. Furthermore,
biodegradability of the substance strongly determines the ability of a
substance to bioaccumulate in organisms. As p-cresol is readily
biodegradable no risk of bioaccumulation arises. Therefore, based on
these properties no adverse effects to birds due to bioaccumulation in
food chains would be expected and there is no need for testing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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