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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Remarks:
other: migrated datset
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature: experimental details are missing, only one dose used

Data source

Reference
Reference Type:
review article or handbook
Title:
Inhalational effect of cresol isomers at low concentrations and means for improving detoxication processes in experiments on white rats
Author:
Pereima VL
Year:
1975
Bibliographic source:
Dissertation, Lvov, pp. 86-90, cited in: IPCS (1995), Environmental Health Criteria Report No. 168 : Cresols, International Programme on Chemical Safety

Materials and methods

Principles of method if other than guideline:
Rats were exposed by inhalation to p-cresol.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: p-cresol, purity not noted

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
migrated dataset

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Remarks:
migrated dataset
Vehicle:
not specified
Remarks:
migrated dataset
Remarks on MMAD:
MMAD / GSD: no data
Details on inhalation exposure:
migrated dataset
Details on analytical verification of doses or concentrations:
migrated dataset
Duration of treatment / exposure:
4 months
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.01 mg/l
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: 2 months
Positive control:
migrated dataset

Examinations

Observations and examinations performed and frequency:
migrated dataset
Sacrifice and pathology:
migrated dataset
Other examinations:
migrated dataset
Statistics:
migrated dataset

Results and discussion

Results of examinations

Details on results:
migrated dataset

Effect levels

Dose descriptor:
LOAEL
Effect level:
0.01 other: mg/l
Sex:
female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Clinical signs of toxicity included loss of appetite, marked emaciation and decreased locomotor activity. Irritative effects, which persisted throughout recovery, were seen on the nose, eye and skin.  Decreased body weight gain and lung weight, increased liver weight, oliguria and dystrophic changes in the lung and liver occurred. Throughout recovery the body weights remained depressed and urinary excretion remained low.

Applicant's summary and conclusion

Executive summary:

Female rats were exposed to p-cresol aerosols. Clinical signs of toxicity included loss of appetite, marked emaciation and decreased locomotor activity. Irritative effects, which persisted throughout recovery, were seen on the nose, eye and skin. Decreased body weight gain and lung weight, increased liver weight, oliguria and dystrophic changes in the lung and liver occurred. Throughout recovery the body weights remained depressed and urinary excretion remained low.