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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Effects of phenolic smoke condensates and their components on hepatic drug metabolizing systems
Author:
Sternitzke A, Legrum W, Netter KJ
Year:
1992
Bibliographic source:
Fd Chem Toxic 30, 771-781
Reference Type:
publication
Title:
Ueber die Wirkung der Cresole und des Liquor Cresoli Saponatus im Vergleich zur Carbolsaeure
Author:
Tollens K
Year:
1905
Bibliographic source:
Arch Exp Path Pharm 52, 220-241

Materials and methods

Principles of method if other than guideline:
other
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: p-cresol, no further data

Test animals

Species:
mouse

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
150 mg/kg bw

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

Mice received a single subcutaneous injection of p-cresol. A LD50 = 150 mg/kg bw was determined.