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EC number: 203-398-6
CAS number: 106-44-5
Overt signs of toxicity at this dose included lethargy, tremors, convulsions
In a subchronic toxicity study according to OECD TG 408 p-cresol was
administered daily to male and female Sprague-Dawley rats by gavage at
dose levels of 0, 50, 175 , 600 mg/kg bw/day diluted in corn oil. Based
on increased mortality, clinical signs including lethargy, exessive
salivation, tremor and occasional convulsions and comas, hepatotoxicity
and nephrotoxicity from 175 mg/kg bw/d onwards. The NOAEL is 50 mg/kg
bw/d (RTI 1988)
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