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EC number: 203-398-6
CAS number: 106-44-5
Reproductive toxicity was examined in a two-generation toxicity study
according to TSCA Health Effects Test Guideline for specific
organ/tissue toxicity - Reproduction/Fertility effects. Sprague-Dawley
rats were given daily 0, 30, 175, or 450 mg/kg bw/day p-cresol in corn
oil by gavage. No effects on fertility were detected despite overt
general toxicity including increased mortality and reduced body weight
gain at 450 mg/kg bw and at >= 175 mg/kg bw/day hypoactivity ataxia,
twitches, tremors, prostration, urine stains, audible respiration and
perioral wetness. Thus, the NOAEL(fertility) was 450 mg/kg bw/day and
the NOAEL(general toxicity) was 30 mg/kg bw/day. The NOAEL(offspring) is
175 mg/kg bw/day due to toxic effects in the F2 litters of the high dose
group animals and no clear evidence of toxic effects in F1 pups.
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