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EC number: 203-468-6
CAS number: 107-15-3
reduction in maternal body weight gain in the intermediate dose group
during gestation day 6 - 15 and in the high dose group during gestation
day 6 - 21; significant decreased diet consumption in the intermediate
and high dose group during gestation day 6 - 15; significant increased
number of resorptions/litter and significant decreased mean fetal body
weight and reduced fetal crown-rump length in the high dose group;
significant higher incidence of a shortened mandible, edematous eye
bulge, shortened or missing innominate artery, unossified sternebrae in
fetuses of the high dose group.
F = fetuses
L = litters
artery to branch off of the aorta is the brachiocephalic which becomes
the innominate after the left carotid branches off. The
innominate then branches into the right subclavian and right carotid
the authors stated it was missing, they really mean that the right and
left carotid branch off of the brachiocephalic artery at the same time.
there is no innominate. However,
this would not affect blood supply to areas served by these arteries.
Fischer 344 rats were fed EDA*2HCl on
gestation day 6-15. Groups of 20 rats were fed doses 50, 250, or 1000
mg/kg. Two control groups were used. Standard endpoints for
teratogenicity were evaluated.
Reduction in maternal body weight gain was noted in the high and
intermediate dose group. Reduced diet consumption was also noted in
those groups. In the high dose group there was an increased number of
resorptions/litter, decreased mean fetal weight and length, higher
incidence of shortened mandible, edematous eye bulge, shortened or
missing sternebrae, delayed ossification and missing, or shortened
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