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EC number: 203-468-6
CAS number: 107-15-3
132 ppm: The death of
4/30 animals was attributed to lung infection (not substance-related);
slight depilation; body weight gain and relative weights of liver and
kidney were not affected; no substance-related macroscopic or histologic
225 ppm: The death of
16/30 was substance-related and another 10 death were considered not to
be substance-related; the 4 rats which survived showed significantly
lower weight gain and higher relative weights of liver and kidney;
cloudy swelling of the liver and of the loop and convoluted tubules of
the kidney; lung congestion was observed in exposed as well as in
control rats in similar proportions.
484 ppm: All rats died within 20 days of initial exposure; depilation
was first observed on the 6th day of exposure; cloudy swelling of the
liver (in 23/28 animals), cloudy swelling and degeneration of convoluted
tubules (in 7/28 animals); congestion of the lung (in 17/28 animals) and
of the adrenal cortex (in 5/28 animals).
59 ppm: No effect on weight gain or organ weights. No depilation. No
significant damage to examined tissues; lung, liver and kidney.
In a 6 week study four exposure groups of 30 Sherman rats (15 female/15
male) were exposed to EDA vapour 7 h /day for 5 days per week. Each
exposure group had a control group. The NOAEC was 144 mg/m³ air
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