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EC number: 203-468-6
CAS number: 107-15-3
Mean survival time of
the exposure group for substance 2 (598 days) was shorter than that of
the singly housed control group (626 days); no treatment-related
macroscopic or histopathologic findings; one mouse of the exposure group
had a dermal fibrosis at application site and another one had a mammary
adenocarcinoma. One sebaceous adenoma of the skin of the thorax was
noted in the control group individually housed.
In the exposure group
for substance 1, 1 mouse had a myxosarcoma at the base of the tail, and
11 animals had mild to moderate dermal fibrosis, suggesting skin
irritation. Survival time did not differ from negative control groups.
3-methylcholanthrene group, 39 of 40 mice had skin tumors including 37
with confirmed squamous cell carcinomas.
The dermal oncogenic potential of
ethylenediamine (EDA) was assessed by applying 25 µ1 of a I% solution in
deionized water to the skin of 50 male C3H/HeJ mice. This was the
highest concentration not producing irritation or weight changes in a
preliminary 2-week study. Two EDA samples (Nos. 1 and 2) from different
production sources were tested. Applications were made thrice weekly
until the death of the animals. A negative control group received
deionized water only. This group and the EDA-treated groups were
individually housed. A fourth group of 40 mice, housed 5 per cage,
received 0.1% 3-methylcholanthrene (MC) in acetone as a positive control
substance. A fifth group of 40 mice, housed 5 per cage, also received
deionized water to determine the effect of group housing on survival. No
skin tumors were observed in the EDA-treated groups. In the positive
control group, however, 39 animals (98%) had skin tumors including 37
(92%) with confirmed squamous cell carcinomas. Eleven mice (22%) which
received EDA No. 1 had dermal fibrosis indicative of probable skin
irritation in this group; there was no such lesion in the controls.
No skin tumors were observed in the EDA
treated animals. In the positive control group 98% of the animals had
Ethylenediamine sample was oncogenic (carcinogenic) to the skin or
systemically under the conditions of this study.
In a dermal
carcinogenicity study, the maximum tolerated dose for local effects was
applied to the back of 50 male mice three times weekly throughout their
lifespan. There were no treatment-related systemic macroscopic or
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