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EC number: 203-468-6
CAS number: 107-15-3
The dermal oncogenic potential of
ethylenediamine (EDA) was assessed by applying 25 µL of a 1% solution in
deionized water to the skin of 50 male C3H/HeJ mice. This was the
highest concentration not producing irritation or weight changes in a
preliminary 2-week study. Two EDA samples (Nos. 1 and 2) from different
production sources were tested. Applications were made three times
weekly until the death of the animals. A negative control group received
deionized water only. This group and the EDA-treated groups were
individually housed. A fourth group of 40 mice, housed 5 per cage,
received 0.1% 3-methylcholanthrene (MC) in acetone as a positive control
substance. A fifth group of 40 mice, housed 5 per cage, also received
deionized water to determine the effect of group housing on survival. No
skin tumors were observed in the EDA-treated groups. In the positive
control group, however, 39 animals (98%) had skin tumors including 37
(92%) with confirmed squamous cell carcinomas. Eleven mice (22%) which
received EDA No. 1 had dermal fibrosis indicative of probable skin
irritation in this group; there was no such lesion in the controls. No
skin tumors were observed in the EDA treated animals.
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