Registration Dossier
Registration Dossier
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EC number: 203-468-6 | CAS number: 107-15-3
Endpoint summary
Administrative data
Description of key information
LD50/LC50 (4 -h) values are based on animal test data for acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 866 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Value:
- 14 700 mg/m³ air
- Quality of whole database:
- This value is for a 4-h LC50
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 560 mg/kg bw
Additional information
In an acute inhalation toxicity test, an 8h LC50 value was calculated as the geometric mean of the LC0 and LC100 value. Calculation using Haber's law, C*t =k (with 'n' is equal to 1), a 4h LC50 value of 14.7 mg/L was obtained. This is supported by another study, with an 8h LC0 value of 11 mg/L.
For acute oral toxicity as a worst case the lowest LD50 was selected.
Justification for classification or non-classification
The following classifications should be used: acute oral and inhalation toxicity GHS cat. 4, for acute dermal toxicity GHS cat. 3.
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