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EC number: 203-468-6
CAS number: 107-15-3
dose group: Diet
and water consumption significantly reduced in the high dose female
rats. Significant reduction in body weight gain of both sexes in the
high dose group; significant reduction in absolute weights of liver and
heart (both sexes), adrenal and brain (female), kidney and spleen (male)
in the high dose group; increase of relative weight of brain (both
sexes), spleen and heart (female) and testis in the high dose group.
Significant elevation of alkaline phosphatase activity in males and
elevation of alanine aminotransferase activity in males and females of
high dose groups. Increased
mean corpuscular volumes in males and females. Significant
increase of mean corpuscular hemoglobin and significant depression of
hematocrit and hemoglobin values; significant depression of red blood
cell counts, serum glucose level and urinary pH (from 6.0 to 5.0) and
significant elevation of aspartate aminotransferase activity in both
sexes of the high dose group; hepatocellular pleomorphism in 7/10 female
and 2/10 male (control: 0/10 of each sex) in high dose group,
hepatocellular degeneration and significant increased
prevalence of tracheitis in male of the high dose group.
dose group: Water
consumption significantly reduced in female rats. Significant elevation
of alanine aminotransferase activity in males of intermediate dose
mean corpuscular volumes in females.
Low dose group: Water
consumption significantly reduced in female rats. Significant
elevation of alkaline phosphatase activity in males, this effect was not
noted in the intermediate dose group.
In a three month dietary study, male and female rats were fed targeted
doses of 0, 50, 250 or 1000 mg/kg/day of EDA-2HCl . There were no deaths
and no abnormal clinical signs noted during the study. Body weight gains
were significantly decreased in the high dose group which affected a
number of absolute and relative organ weights in both males and females. Water
consumption was comparable to control values at all dose levels in males
but was decreased in a dose-response manner in female rats at all 3 dose
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