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EC number: 203-468-6
CAS number: 107-15-3
Skin responses were evaluated and scored. 45% of animals tested showed
signs of sensitisation.
In a Guinea Pig Maximisation test ethylene diamine was a sensitiser.
Cross sensitisation with other ethylene amine substances was observed.
Based on the available Guinea Pig Maximisation study, with an
intradermal induction of 5%, and based on moderate effects in humans a
category of 1B is justified.
In 1999 the World Health Organization
published their Concise International Chemical assessment Document 15 on
1,2 –Diaminoethane (ethylenediamine). This document referenced several
case reports of respiratory senitisation apparently due to exposure to
ethylene daimine but the incidence was not specified other than in one
report when it was quoted to be 10%. This was a retrospective study so
no challenge tests were done. Aldrich, FD, Strange AW and Geesman RE
published in 1987 Smoking and ethylenediamine sensization in an
industrial population, J. Occup Med 1987 Apr; 29(4) 311-314., from the
abstract the incidence they was 38 out of 337 workers ca. 11%.
The paper by Lars Hagmar, MD et.al,
Piperazine induced Occupational Asthma, Journal of occupational
Medicine, Vol 24 No 3. March 1982, mention 2 individuals sensitized in a
population of 130 workers, who had been exposed to ethylenediamine which
was used until the previous year i.e. ca, 3% incidence.
In a large review paper authored by M.
Chan-Yeung and J-L. Malo, Aetiological agents in occupational asthma in
the Eur Resp J 194, 7 , 346-371, they reviewed about 200 agents
implicated in occupational asthma. While they only included some case
reports for ethylene diamine they did give percentage incidence values
for some known strong respiratory sensitisers such as the diisocyanates,
including TDI and HDI and some anhydrides. For these the percentage
incidences were in the order of 28-35%. As we would expect these
substances to be classified as 1A for respiratory sensitization we see
this level of incidence being necessary to support a conclusion of high
frequency. Based on this we would interpret the incidence of ca. 3-11%
seen with ethylene diamine as being in the low to moderate frequency
range and therefore supporting a classification of 1B. None of the
admittedly limited available information supports a conclusion of 1A.
So we recommend that ethylenediamine be
classified as 1B for respiratory sernsitisation based on the above
Ethylene diamine is classified as a skin and respiratory sensitiser.
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